In a report published late last month in the medical journal The BMJ , a group of American and Chinese researchers raise potential safety concerns about GLP-1 drugs, indicating that higher doses of the drugs were linked to increased risks of experiencing symptoms consistent with stomach paralysis, including persistent nausea, vomiting and irregular bowel movements
Aging Cell 16 (5), 10731082
Disease models studied include rheumatoid arthritis, psoriatic arthritis, lupus, multiple sclerosis (EAE), psoriasis, gouty arthritis, and metabolic inflammation
At the chemical class level, we observed apparent shifts in chemical subclasses
This protective action may possibly be due to its effect of preserving the cellular membrane of the hepatocytes from breakage by the reactive metabolites [45]